VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease

Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Guo, Xing, Sun, XiaoYan, Hu, Di, Wang, Ya-Juan, Fujioka, Hisashi, Vyas, Rajan, Chakrapani, Sudha, Joshi, Amit Umesh, Luo, Yu, Mochly-Rosen, Daria, Qi, Xin
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007466/
https://ncbi.nlm.nih.gov/pubmed/27561680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12646
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