VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease

Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our proteomic analysis identifies valosin-containing protein (VCP) as an mtHtt-binding protein on the mitochondria. Here we show...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Guo, Xing, Sun, XiaoYan, Hu, Di, Wang, Ya-Juan, Fujioka, Hisashi, Vyas, Rajan, Chakrapani, Sudha, Joshi, Amit Umesh, Luo, Yu, Mochly-Rosen, Daria, Qi, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007466/
https://ncbi.nlm.nih.gov/pubmed/27561680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12646
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