Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease

Some cases of familial amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding cytosolic, copper–zinc superoxide dismutase (SOD1). We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Nagai, Makiko, Aoki, Masashi, Miyoshi, Ichiro, Kato, Masaaki, Pasinelli, Piera, Kasai, Noriyuki, Brown, Robert H., Itoyama, Yasuto
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763929/
https://ncbi.nlm.nih.gov/pubmed/11717358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-23-09246.2001
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