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Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease

Some cases of familial amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding cytosolic, copper–zinc superoxide dismutase (SOD1). We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor...

詳細記述

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書誌詳細
出版年:J Neurosci
主要な著者: Nagai, Makiko, Aoki, Masashi, Miyoshi, Ichiro, Kato, Masaaki, Pasinelli, Piera, Kasai, Noriyuki, Brown, Robert H., Itoyama, Yasuto
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2001
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763929/
https://ncbi.nlm.nih.gov/pubmed/11717358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-23-09246.2001
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