Rats Expressing Human Cytosolic Copper–Zinc Superoxide Dismutase Transgenes with Amyotrophic Lateral Sclerosis: Associated Mutations Develop Motor Neuron Disease

Some cases of familial amyotrophic lateral sclerosis (ALS) are caused by mutations in the gene encoding cytosolic, copper–zinc superoxide dismutase (SOD1). We report here that rats that express a human SOD1 transgene with two different ALS-associated mutations (G93A and H46R) develop striking motor...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Nagai, Makiko, Aoki, Masashi, Miyoshi, Ichiro, Kato, Masaaki, Pasinelli, Piera, Kasai, Noriyuki, Brown, Robert H., Itoyama, Yasuto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2001
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ARTICLE
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763929/
https://ncbi.nlm.nih.gov/pubmed/11717358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-23-09246.2001
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