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Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor

The shikimate pathway, a metabolic pathway absent in humans, is responsible for the production of chorismate, a branch point metabolite. In the malaria parasite, chorismate is postulated to be a direct precursor in the synthesis of p-aminobenzoic acid (folate biosynthesis), p-hydroxybenzoic acid (ub...

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Detalles Bibliográficos
Publicado en:Sci Rep
Main Authors: Valenciano, Ana Lisa, Fernández-Murga, Maria L., Merino, Emilio F., Holderman, Nicole R., Butschek, Grant J., Shaffer, Karl J., Tyler, Peter C., Cassera, Maria Belen
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763611/
https://ncbi.nlm.nih.gov/pubmed/31558748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50319-5
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