STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

The stimulator of IFN genes (STING) signaling pathway is a critical link between innate and adaptive immunity and induces antitumor immune responses. STING is expressed in vasculatures, but its role in tumor angiogenesis has not been elucidated. Here, we investigated STING-induced tumor vascular rem...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yang, Hannah, Lee, Won Suk, Kong, So Jung, Kim, Chang Gon, Kim, Joo Hoon, Chang, Sei Kyung, Kim, Sewha, Kim, Gwangil, Chon, Hong Jae, Kim, Chan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763266/
https://ncbi.nlm.nih.gov/pubmed/31343989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125413
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