STING activation reprograms tumor vasculatures and synergizes with VEGFR2 blockade

The stimulator of IFN genes (STING) signaling pathway is a critical link between innate and adaptive immunity and induces antitumor immune responses. STING is expressed in vasculatures, but its role in tumor angiogenesis has not been elucidated. Here, we investigated STING-induced tumor vascular rem...

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Vydáno v:J Clin Invest
Hlavní autoři: Yang, Hannah, Lee, Won Suk, Kong, So Jung, Kim, Chang Gon, Kim, Joo Hoon, Chang, Sei Kyung, Kim, Sewha, Kim, Gwangil, Chon, Hong Jae, Kim, Chan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763266/
https://ncbi.nlm.nih.gov/pubmed/31343989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI125413
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