Degradation of splicing factor SRSF3 contributes to progressive liver disease

Serine-rich splicing factor 3 (SRSF3) plays a critical role in liver function and its loss promotes chronic liver damage and regeneration. As a consequence, genetic deletion of SRSF3 in hepatocytes caused progressive liver disease and ultimately led to hepatocellular carcinoma. Here we show that SRS...

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Bibliografiske detaljer
Udgivet i:J Clin Invest
Main Authors: Kumar, Deepak, Das, Manasi, Sauceda, Consuelo, Ellies, Lesley G., Kuo, Karina, Parwal, Purva, Kaur, Mehak, Jih, Lily, Bandyopadhyay, Gautam K., Burton, Douglas, Loomba, Rohit, Osborn, Olivia, Webster, Nicholas J.G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763247/
https://ncbi.nlm.nih.gov/pubmed/31393851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI127374
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