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Deletion of Splicing Factor SRSF3 in Hepatocytes Predisposes to Hepatocellular Carcinoma in Mice
Alterations in RNA splicing are associated with cancer, but it is not clear whether they result from malignant transformation or have a causative role. We show here that hepatocyte-specific deletion of splicing factor SRSF3 impairs hepatocyte maturation and metabolism in early adult life, and mice d...
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| Published in: | Hepatology |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4280350/ https://ncbi.nlm.nih.gov/pubmed/25132062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27380 |
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