Expression of A53T Mutant But Not Wild-Type α-Synuclein in PC12 Cells Induces Alterations of the Ubiquitin-Dependent Degradation System, Loss of Dopamine Release, and Autophagic Cell Death

α-Synuclein mutations have been identified in certain families with Parkinson's disease (PD), and α-synuclein is a major component of Lewy bodies. Other genetic data indicate that the ubiquitin-dependent proteolytic system is involved in PD pathogenesis. We have generated stable PC12 cell lines...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Stefanis, Leonidas, Larsen, Kristin E., Rideout, Hardy J., Sulzer, David, Greene, Lloyd A.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763041/
https://ncbi.nlm.nih.gov/pubmed/11739566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-24-09549.2001
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