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Potentiation of Opioid Analgesia in Dopamine(2)Receptor Knock-Out Mice: Evidence for a Tonically Active Anti-Opioid System

Dopamine systems are intimately involved with opioid actions. Pharmacological studies suggest an important modulatory effect of dopamine and its receptors on opioid analgesia. We have now examined these interactions in a knock-out model in which the dopamine(2) (D(2)) receptor has been disrupted. Lo...

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Détails bibliographiques
Publié dans:J Neurosci
Auteurs principaux: King, Michael A., Bradshaw, Sheri, Chang, Albert H., Pintar, John E., Pasternak, Gavril W.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2001
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762878/
https://ncbi.nlm.nih.gov/pubmed/11567069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-19-07788.2001
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