Demonstration by Fluorescence Resonance Energy Transfer of Two Sites of Interaction between the Low-Density Lipoprotein Receptor-Related Protein and the Amyloid Precursor Protein: Role of the Intracellular Adapter Protein Fe65

Amyloid-β, the major constituent of senile plaques in Alzheimer's disease, is derived from the amyloid precursor protein (APP) by proteolysis. Kunitz protease inhibitor (KPI) containing forms of APP (APP751/770) interact with a multifunctional endocytic receptor, the low-density lipoprotein rec...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Kinoshita, Ayae, Whelan, Christa M., Smith, Carolyn J., Mikhailenko, Irena, Rebeck, G. William, Strickland, Dudley K., Hyman, Bradley T.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762817/
https://ncbi.nlm.nih.gov/pubmed/11606623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-21-08354.2001
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