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The Surface Accessibility of the Glycine Receptor M2–M3 Loop Is Increased in the Channel Open State

Mutations in the extracellular M2–M3 loop of the glycine receptor (GlyR) α1 subunit have been shown previously to affect channel gating. In this study, the substituted cysteine accessibility method was used to investigate whether a structural rearrangement of the M2–M3 loop accompanies GlyR activati...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Lynch, Joseph W., Han, Nian-Lin Reena, Haddrill, Justine, Pierce, Kerrie D., Schofield, Peter R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762528/
https://ncbi.nlm.nih.gov/pubmed/11306612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-08-02589.2001
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