Cation-selective Mutations in the M2 Domain of the Inhibitory Glycine Receptor Channel Reveal Determinants of Ion-Charge Selectivity

Ligand-gated ion channel receptors mediate neuronal inhibition or excitation depending on their ion charge selectivity. An investigation into the determinants of ion charge selectivity of the anion-selective α1 homomeric glycine receptor (α1 glycine receptor [GlyR]) was undertaken using point mutati...

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Detalhes bibliográficos
Main Authors: Keramidas, Angelo, Moorhouse, Andrew J., Pierce, Kerrie D., Schofield, Peter R., Barry, Peter H.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233820/
https://ncbi.nlm.nih.gov/pubmed/11981020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028552
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