NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) is a mitochondria-located innate immune sensor that inhibits major pro-inflammatory pathways such as type I interferon and nuclear factor-κB signaling. We generated a novel, spontaneous, and rapidly progressing mouse model of multiple scl...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Biol
Main Authors: Gharagozloo, Marjan, Mahmoud, Shaimaa, Simard, Camille, Yamamoto, Kenzo, Bobbala, Diwakar, Ilangumaran, Subburaj, Smith, Matthew D., Lamontagne, Albert, Jarjoura, Samir, Denault, Jean-Bernard, Blais, Véronique, Gendron, Louis, Vilariño-Güell, Carles, Sadovnick, A. Dessa, Ting, Jenny P., Calabresi, Peter A., Amrani, Abdelaziz, Gris, Denis
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762215/
https://ncbi.nlm.nih.gov/pubmed/31525189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000451
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki