Inhibition of Senescence‐Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post–Myocardial Infarction

BACKGROUND: Myocardial infarction results in a large‐scale cardiomyocyte loss and heart failure due to subsequent pathological remodeling. Whereas zebrafish and neonatal mice have evident cardiomyocyte expansion following injury, adult mammalian cardiomyocytes are principally nonproliferative. Despi...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Alam, Perwez, Haile, Bereket, Arif, Mohammed, Pandey, Raghav, Rokvic, Miso, Nieman, Michelle, Maliken, Bryan D., Paul, Arghya, Wang, Yi‐Gang, Sadayappan, Sakthivel, Ahmed, Rafeeq P. H., Kanisicak, Onur
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761626/
https://ncbi.nlm.nih.gov/pubmed/31315484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.119.012089
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