Lentiviral CRISPR Epigenome Editing of Inflammatory Receptors as a Gene Therapy Strategy for Disc Degeneration

Degenerative disc disease (DDD) is a primary contributor to low-back pain, a leading cause of disability. Progression of DDD is aided by inflammatory cytokines in the intervertebral disc (IVD), particularly TNF-α and IL-1β, but current treatments fail to effectively target this mechanism. The object...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Farhang, Niloofar, Ginley-Hidinger, Matt, Berrett, Kristofer C., Gertz, Jason, Lawrence, Brandon, Bowles, Robby D.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761595/
https://ncbi.nlm.nih.gov/pubmed/31140325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2019.005
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