CRISPR Epigenome Editing of AKAP150 in DRG Neurons Abolishes Degenerative IVD-Induced Neuronal Activation

Back pain is a major contributor to disability and has significant socioeconomic impacts worldwide. The degenerative intervertebral disc (IVD) has been hypothesized to contribute to back pain, but a better understanding of the interactions between the degenerative IVD and nociceptive neurons innerva...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Stover, Joshua D., Farhang, Niloofar, Berrett, Kristofer C., Gertz, Jason, Lawrence, Brandon, Bowles, Robby D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589089/
https://ncbi.nlm.nih.gov/pubmed/28676344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.010
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