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Short-acting anti-VWF aptamer improves the recovery, survival, and hemostatic functions of refrigerated platelets

OBJECTIVE: Refrigeration-induced binding of von Willebrand factor (VWF) to platelets contributes to the rapid clearance of refrigerated platelets. In this study, we investigate whether inhibiting VWF binding by a DNA-based aptamer ameliorates the clearance of refrigerated platelets without significa...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Chen, Wenchun, Voos, Kayleigh M., Josephson, Cassandra D., Li, Renhao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6761020/
https://ncbi.nlm.nih.gov/pubmed/31315441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312439
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