Inhibiting GPIbα shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage

OBJECTIVES: The platelet storage lesion accelerates platelet clearance after transfusion, but the underlying molecular mechanism remains elusive. Although inhibiting sheddase activity hampers clearance of platelets with storage lesion, the target platelet protein responsible for ectodomain shedding-...

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Vydáno v:Arterioscler Thromb Vasc Biol
Hlavní autoři: Chen, Wenchun, Liang, Xin, Syed, Anum K., Jessup, Paula, Church, William R., Ware, Jerry, Josephson, Cassandra D., Li, Renhao
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001887/
https://ncbi.nlm.nih.gov/pubmed/27417583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.307639
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