Mechanism of enhanced MerTK-dependent macrophage efferocytosis by extracellular vesicles

OBJECTIVE: Extracellular vesicles secreted by cardiosphere-derived cells (CDC(ev)) polarize macrophages (Mϕ) toward a distinctive phenotype with enhanced phagocytic capacity (M(CDCev)). These changes underlie cardioprotection by CDC(ev) and by the parent CDCs, notably attenuating the “no reflow” phe...

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Bibliographic Details
Published in:Arterioscler Thromb Vasc Biol
Main Authors: de Couto, Geoffrey, Jaghatspanyan, Ervin, DeBerge, Matthew, Liu, Weixin, Luther, Kristin, Wang, Yizhou, Tang, Jie, Thorp, Edward B., Marbán, Eduardo
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760997/
https://ncbi.nlm.nih.gov/pubmed/31434491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.313115
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