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A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in turn, trigger epithelial-mesenchymal transiti...
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| 出版年: | PLoS One |
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| 主要な著者: | , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2019
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6760769/ https://ncbi.nlm.nih.gov/pubmed/31553741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222331 |
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