A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction

Podoplanin, a transmembrane glycoprotein, is overexpressed in certain types of tumors and induces platelet aggregation by binding to C-type lectin-like receptor 2 (CLEC-2) on the platelet membrane. Activated platelets release granule components, which in turn, trigger epithelial-mesenchymal transiti...

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Udgivet i:PLoS One
Main Authors: Watanabe, Nobuo, Kidokoro, Masako, Suzuki, Yusuke, Tanaka, Makiko, Inoue, Shigeaki, Tsukamoto, Hideo, Hirayama, Noriaki, Hsieh, Pei-Wen, Tseng, Ching-Ping, Nakagawa, Yoshihide, Inokuchi, Sadaki
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760769/
https://ncbi.nlm.nih.gov/pubmed/31553741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0222331
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