Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

BACKGROUND/OBJECTIVES: Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to replacement therapy. Recombinant leptin is however largely ineffective for the vast majority of obese individuals due to leptin resistance. One th...

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Publicat a:Int J Obes (Lond)
Autors principals: Harrison, Luke, Schriever, Sonja C., Feuchtinger, Annette, Kyriakou, Eleni, Baumann, Peter, Pfuhlmann, Katrin, Messias, Ana C., Walch, Axel, Tschöp, Matthias H., Pfluger, Paul T.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760579/
https://ncbi.nlm.nih.gov/pubmed/30283080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-018-0221-z
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