Fluorescent blood–brain barrier tracing shows intact leptin transport in obese mice

BACKGROUND/OBJECTIVES: Individuals carrying loss-of-function gene mutations for the adipocyte hormone leptin are morbidly obese, but respond favorably to replacement therapy. Recombinant leptin is however largely ineffective for the vast majority of obese individuals due to leptin resistance. One th...

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Bibliografiske detaljer
Udgivet i:Int J Obes (Lond)
Main Authors: Harrison, Luke, Schriever, Sonja C., Feuchtinger, Annette, Kyriakou, Eleni, Baumann, Peter, Pfuhlmann, Katrin, Messias, Ana C., Walch, Axel, Tschöp, Matthias H., Pfluger, Paul T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760579/
https://ncbi.nlm.nih.gov/pubmed/30283080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41366-018-0221-z
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