Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population

BACKGROUND: Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PCa specimens. Mutations in BRCA2 vary in racial and ethnic groups including A...

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Veröffentlicht in:Prostate Cancer Prostatic Dis
Hauptverfasser: Petrovics, Gyorgy, Price, Douglas K., Lou, Hong, Chen, Yongmei, Garland, Lisa, Bass, Sara, Jones, Kristine, Kohaar, Indu, Ali, Amina, Ravindranath, Lakshmi, Young, Denise, Cullen, Jennifer, Dorsey, Tiffany H., Sesterhenn, Isabell A., Brassell, Stephen A., Rosner, Inger L., Ross, Doug, Dahut, William, Ambs, Stefan, Figg, William Douglas, Srivastava, Shiv, Dean, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760554/
https://ncbi.nlm.nih.gov/pubmed/30542053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-018-0114-1
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