Increased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population

BACKGROUND: Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PCa specimens. Mutations in BRCA2 vary in racial and ethnic groups including A...

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發表在:Prostate Cancer Prostatic Dis
Main Authors: Petrovics, Gyorgy, Price, Douglas K., Lou, Hong, Chen, Yongmei, Garland, Lisa, Bass, Sara, Jones, Kristine, Kohaar, Indu, Ali, Amina, Ravindranath, Lakshmi, Young, Denise, Cullen, Jennifer, Dorsey, Tiffany H., Sesterhenn, Isabell A., Brassell, Stephen A., Rosner, Inger L., Ross, Doug, Dahut, William, Ambs, Stefan, Figg, William Douglas, Srivastava, Shiv, Dean, Michael
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760554/
https://ncbi.nlm.nih.gov/pubmed/30542053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41391-018-0114-1
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