Conformational characterization of full-length X-chromosome-linked inhibitor of apoptosis protein (XIAP) through an integrated approach

The X-chromosome-linked inhibitor of apoptosis protein (XIAP) is a multidomain protein whose main function is to block apoptosis by caspase inhibition. XIAP is also involved in other signalling pathways, including NF-κB activation and copper homeostasis. XIAP is overexpressed in tumours, potentiatin...

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Detalles Bibliográficos
Publicado en:IUCrJ
Main Authors: Polykretis, Panagis, Luchinat, Enrico, Bonucci, Alessio, Giachetti, Andrea, Graewert, Melissa A., Svergun, Dmitri I., Banci, Lucia
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2019
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760453/
https://ncbi.nlm.nih.gov/pubmed/31576227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S205225251901073X
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