GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity

In 1997, our laboratory used targeted gene disruption of the GH receptor (GHR) to generate GHR knockout (GHR(−/−)) mice, which have been used in >127 published studies to help elucidate GH’s numerous activities. However, because GH replacement studies cannot be performed using this line, a GH kno...

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Dettagli Bibliografici
Pubblicato in:Endocrinology
Autori principali: List, Edward O, Berryman, Darlene E, Buchman, Mathew, Jensen, Elizabeth A, Funk, Kevin, Duran-Ortiz, Silvana, Qian, Yanrong, Young, Jonathan A, Slyby, Julie, McKenna, Savannah, Kopchick, John J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760334/
https://ncbi.nlm.nih.gov/pubmed/31099824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2019-00167
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