Developing a Versatile Shotgun Cloning Strategy for Single-Vector-Based Multiplex Expression of Short Interfering RNAs (siRNAs) in Mammalian Cells

[Image: see text] As an important post-transcriptional regulatory machinery mediated by ∼21nt short-interfering double-stranded RNA (siRNA), RNA interference (RNAi) is a powerful tool to delineate gene functions and develop therapeutics. However, effective RNAi-mediated silencing requires multiple s...

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Библиографические подробности
Опубликовано в: :ACS Synth Biol
Главные авторы: Wang, Xi, Yuan, Chengfu, Huang, Bo, Fan, Jiaming, Feng, Yixiao, Li, Alexander J., Zhang, Bo, Lei, Yan, Ye, Zhenyu, Zhao, Ling, Cao, Daigui, Yang, Lijuan, Wu, Di, Chen, Xian, Liu, Bin, Wagstaff, William, He, Fang, Wu, Xiaoxing, Luo, Huaxiu, Zhang, Jing, Zhang, Meng, Haydon, Rex C., Luu, Hue H., Lee, Michael J., Moriatis Wolf, Jennifer, Huang, Ailong, He, Tong-Chuan, Zeng, Zongyue
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760290/
https://ncbi.nlm.nih.gov/pubmed/31465214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acssynbio.9b00203
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