Identification of the PTEN-ARID4B-PI3K pathway reveals the dependency on ARID4B by PTEN-deficient prostate cancer

PTEN is frequently mutated in prostate cancer. The tumor suppressor function of PTEN is attributed to its lipid phosphatase activity that counters PI3K action. Here, we report a PTEN-ARID4B-PI3K axis in which PTEN inhibits expression of ARID4B, while ARID4B is a transcriptional activator of the PI3K...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Wu, Ray-Chang, Young, In-Chi, Chen, Yu-Fang, Chuang, Sung-Ting, Toubaji, Antoun, Wu, Mei-Yi
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760172/
https://ncbi.nlm.nih.gov/pubmed/31551414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12184-8
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