Inhibition of casein kinase 1δ/εimproves cognitive-affective behavior and reduces amyloid load in the APP-PS1 mouse model of Alzheimer’s disease

Circadian rhythm disruption is one of the earliest biomarkers of Alzheimer’s disease (AD), and there exists a bidirectional relationship by which dysfunctions in the circadian clock drive AD pathology and AD pathology drives circadian dysfunction. Casein kinase 1 (CK1) isoforms ε and δ, key circadia...

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Pubblicato in:Sci Rep
Autori principali: Sundaram, S., Nagaraj, S., Mahoney, H., Portugues, A., Li, W., Millsaps, K., Faulkner, J., Yunus, A., Burns, C., Bloom, C., Said, M., Pinto, L., Azam, S., Flores, M., Henriksen, A., Gamsby, J., Gulick, D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6760153/
https://ncbi.nlm.nih.gov/pubmed/31551449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50197-x
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