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Effect of iron oxide nanoparticles on the oxidation and secondary structure of growth hormone
Oxidation of therapeutic proteins (TPs) can lead to changes in their pharmacokinetics, biological activity and immunogenicity. Metal impurities such as iron are known to increase oxidation of TPs, but nanoparticulate metals have unique physical and chemical properties compared to the bulk material o...
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| Udgivet i: | J Pharm Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6759409/ https://ncbi.nlm.nih.gov/pubmed/31216451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2019.06.007 |
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