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A phosphorylation-deficient mutant of retinoid X receptor α at Thr167 alters fasting response and energy metabolism in mice
Retinoid X receptor α (RXRα) has a conserved phosphorylation motif at threonine 162 (humans) and threonine 167 (mice) within the DNA binding domain. Here we have generated RXRα knock-in mice (Rxrα(T167A)) bearing a single mutation of Thr167 to alanine and examined the roles of Thr167 in the regulati...
Shranjeno v:
| izdano v: | Lab Invest |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6759383/ https://ncbi.nlm.nih.gov/pubmed/31152145 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41374-019-0266-1 |
| Oznake: |
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