Cancer vaccine strategies: translation from mice to human clinical trials

We translated two cancer vaccine strategies from mice into human clinical trials. (1) In preclinical studies on TARP, an antigen expressed in most prostate cancers, we mapped epitopes presented by HLA-A*0201, modified them to increase affinity and immunogenicity in HLA transgenic mice, and induced h...

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Podrobná bibliografie
Vydáno v:Cancer Immunol Immunother
Hlavní autoři: Berzofsky, Jay A., Terabe, Masaki, Trepel, Jane B., Pastan, Ira, Stroncek, David F., Morris, John C., Wood, Lauren V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2017
Témata:
Focussed Research Review
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759211/
https://ncbi.nlm.nih.gov/pubmed/29143114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-017-2084-x
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