Cancer vaccine strategies: translation from mice to human clinical trials

We translated two cancer vaccine strategies from mice into human clinical trials. (1) In preclinical studies on TARP, an antigen expressed in most prostate cancers, we mapped epitopes presented by HLA-A*0201, modified them to increase affinity and immunogenicity in HLA transgenic mice, and induced h...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Immunother
Main Authors: Berzofsky, Jay A., Terabe, Masaki, Trepel, Jane B., Pastan, Ira, Stroncek, David F., Morris, John C., Wood, Lauren V.
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2017
Fag:
Focussed Research Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6759211/
https://ncbi.nlm.nih.gov/pubmed/29143114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-017-2084-x
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