Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic l-Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat Model of Parkinson's Disease.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. This loss leads to complete dopamine depletion in the striatum and severe motor impairment. It has been demonstrated previously that a lentiviral vector...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Azzouz, Mimoun, Martin-Rendon, Enca, Barber, Robert D., Mitrophanous, Kyriacos A., Carter, Emma E., Rohll, Jonathan B., Kingsman, Susan M., Kingsman, Alan J., Mazarakis, Nicholas D.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2002
Fag:
ARTICLE
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758736/
https://ncbi.nlm.nih.gov/pubmed/12451130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-23-10302.2002
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker