Multicistronic Lentiviral Vector-Mediated Striatal Gene Transfer of Aromatic l-Amino Acid Decarboxylase, Tyrosine Hydroxylase, and GTP Cyclohydrolase I Induces Sustained Transgene Expression, Dopamine Production, and Functional Improvement in a Rat Model of Parkinson's Disease.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra. This loss leads to complete dopamine depletion in the striatum and severe motor impairment. It has been demonstrated previously that a lentiviral vector...

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Publicado no:J Neurosci
Main Authors: Azzouz, Mimoun, Martin-Rendon, Enca, Barber, Robert D., Mitrophanous, Kyriacos A., Carter, Emma E., Rohll, Jonathan B., Kingsman, Susan M., Kingsman, Alan J., Mazarakis, Nicholas D.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758736/
https://ncbi.nlm.nih.gov/pubmed/12451130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-23-10302.2002
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