Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not known how TBI contributes to the onset or progression of this common late life dementia. To address this question, we studied neuropathological and behavioral consequences of single versus repetitiv...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Uryu, Kunihiro, Laurer, Helmut, McIntosh, Tracy, Praticò, Domenico, Martinez, Daniel, Leight, Susan, Lee, Virginia M.-Y., Trojanowski, John Q.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2002
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758680/
https://ncbi.nlm.nih.gov/pubmed/11784789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-02-00446.2002
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