Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis

Oxidative stress is a key feature in the Alzheimer's disease (AD) brain and manifests as lipid peroxidation (LPO). Isoprostanes (iPs) are specific and sensitive markers of in vivo LPO. To determine whether amyloid β (Aβ) deposition in vivois associated with increased LPO, we examined iP levels...

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Publicat a:J Neurosci
Autors principals: Praticò, Domenico, Uryu, Kunihiro, Leight, Susan, Trojanoswki, John Q., Lee, Virginia M.-Y.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2001
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ARTICLE
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6762743/
https://ncbi.nlm.nih.gov/pubmed/11404403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.21-12-04183.2001
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