Contrasting, Species-Dependent Modulation of Copper-Mediated Neurotoxicity by the Alzheimer's Disease Amyloid Precursor Protein

The amyloid precursor protein (APP) of Alzheimer's disease (AD) has a copper binding domain (CuBD) located in the N-terminal cysteine-rich region that can strongly bind copper(II) and reduce it to Cu(I) in vitro. The CuBD sequence is similar among the APP family paralogs [amyloid precursor-like...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: White, Anthony R., Multhaup, Gerd, Galatis, Denise, McKinstry, William J., Parker, Michael W., Pipkorn, Rüdiger, Beyreuther, Konrad, Masters, Colin L., Cappai, Roberto
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2002
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ARTICLE
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6758658/
https://ncbi.nlm.nih.gov/pubmed/11784781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-02-00365.2002
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