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Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
A neuropathological hallmark of Alzheimer's disease is the deposition of amyloid-β (Aβ) peptides in senile plaques in the hippocampus and cerebral cortex. Aβ is derived from larger integral membrane proteins termed amyloid precursor proteins (APP). We demonstrated previously that APP, synthesiz...
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| Pubblicato in: | J Neurosci |
|---|---|
| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6757836/ https://ncbi.nlm.nih.gov/pubmed/12427834 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-22-09785.2002 |
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