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Structure/Function Analysis of Ca(2+) Binding to the C(2)A Domain of Synaptotagmin 1

Synaptotagmin 1, a Ca(2+) sensor for fast synaptic vesicle exocytosis, contains two C(2) domains that form Ca(2+)-dependent complexes with phospholipids. To examine the functional importance of Ca(2+) binding to the C(2)A domain of synaptotagmin 1, we studied two C(2)A domain mutations, D232N and D2...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Fernández-Chacón, Rafael, Shin, Ok-Ho, Königstorfer, Andreas, Matos, Maria F., Meyer, Alexander C., Garcia, Jesus, Gerber, Stefan H., Rizo, Josep, Südhof, Thomas C., Rosenmund, Christian
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757773/
https://ncbi.nlm.nih.gov/pubmed/12351718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.22-19-08438.2002
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