In vivo and in vitro toxicity evaluation of liposome-encapsulated sirolimus

BACKGROUND: To evaluate the in vivo and in vitro toxicity of a new formulation of liposome-encapsulated sirolimus (LES). METHODS: In vitro experiments were done using ARPE-19 and HRP cells. An MTT assay was used to determine cell metabolic activity and a TUNEL assay for detecting DNA fragmentation....

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Bibliografske podrobnosti
izdano v:Int J Retina Vitreous
Main Authors: Abud, Murilo Batista, Louzada, Ricardo Noguera, Isaac, David Leonardo Cruvinel, Souza, Leonardo Gomes, dos Reis, Ricardo Gomes, Lima, Eliana Martins, de Ávila, Marcos Pereira
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757363/
https://ncbi.nlm.nih.gov/pubmed/31572617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40942-019-0186-7
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