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Improved pharmacokinetics and reduced toxicity of brucine after encapsulation into stealth liposomes: role of phosphatidylcholine

OBJECTIVE: Brucine was encapsulated into stealth liposomes using the ammonium sulfate gradient method to improve therapeutic index. MATERIALS AND METHODS: Four brucine stealth liposomal formulations were prepared, which were made from different phosphatidylcholines (PCs) with different phase transit...

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Detalhes bibliográficos
Main Authors: Chen, Jun, Yan, Guo-jun, Hu, Rong-rong, Gu, Qian-wen, Chen, Ming-lei, Gu, Wei, Chen, Zhi-peng, Cai, Bao-chang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418081/
https://ncbi.nlm.nih.gov/pubmed/22904620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S32860
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