Identification of a Small-Molecule Inhibitor of HIV-1 Assembly that Targets the Phosphatidylinositol (4,5)-bisphosphate Binding Site of the HIV-1 Matrix Protein

The development of drug resistance remains a critical problem for current HIV-1 antiviral therapies, creating a need for new inhibitors of HIV-1 replication. We previously reported on a novel anti-HIV-1 compound, N(2)-(phenoxyacetyl)-N-[4-(1-piperidinyl-carbonyl)benzyl]glycinamide (14), that binds t...

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Bibliographic Details
Published in:ChemMedChem
Main Authors: Zentner, Isaac, Sierra, Luz-Jeannette, Fraser, Ayesha K., Maciunas, Lina, Mankowski, Marie K., Vinnik, Andrei, Fedichev, Peter, Ptak, Roger G., Martín-García, Julio, Cocklin, Simon
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757327/
https://ncbi.nlm.nih.gov/pubmed/23361947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201200577
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