Hexokinase II inhibition by 3-bromopyruvate sensitizes myeloid leukemic cells K-562 to anti-leukemic drug, daunorubicin

An increased metabolic flux towards Warburg phenotype promotes survival, proliferation and causes therapeutic resistance, in leukemic cells. Hexokinase-II (HK-II) is expressed predominantly in cancer cells, which promotes Warburg metabolic phenotype and protects the cancer cells from drug-induced ap...

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Uloženo v:
Podrobná bibliografie
Vydáno v:Biosci Rep
Hlavní autoři: Rai, Yogesh, Yadav, Priyanshu, Kumari, Neeraj, Kalra, Namita, Bhatt, Anant Narayan
Médium: Artigo
Jazyk:Inglês
Vydáno: Portland Press Ltd. 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757186/
https://ncbi.nlm.nih.gov/pubmed/31506393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20190880
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