Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition

Metabolic viability based high throughput assays like MTT and MTS are widely used in assessing the cell viability. However, alteration in both mitochondrial content and metabolism can influence the metabolic viability of cells and radiation is a potential mitochondrial biogenesis inducer. Therefore,...

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Publicado no:Sci Rep
Main Authors: Rai, Yogesh, Pathak, Richa, Kumari, Neeraj, Sah, Dhananjay Kumar, Pandey, Sanjay, Kalra, Namita, Soni, Ravi, Dwarakanath, B. S., Bhatt, Anant Narayan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5784148/
https://ncbi.nlm.nih.gov/pubmed/29367754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19930-w
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