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E3 Ubiquitin Ligase RNF125 Activates Interleukin-36 Receptor Signaling and Contributes to Its Turnover

Signaling by the interleukin-36 receptor (IL-36R) is linked to inflammatory diseases such as psoriasis. However, the regulation of IL-36R signaling is poorly understood. Activation of IL-36R signaling in cultured cells results in an increased polyubiquitination of the receptor subunit, IL-1Rrp2. Tre...

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Bibliografiske detaljer
Udgivet i:J Innate Immun
Main Authors: Saha, Siddhartha S., Caviness, Gary, Yi, Guanghui, Raymond, Ernest L., Mbow, M. Lamine, Kao, C. Cheng
Format: Artigo
Sprog:Inglês
Udgivet: S. Karger AG 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757159/
https://ncbi.nlm.nih.gov/pubmed/29176319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000481210
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