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T CELL REGULATOR RNF125/TRAC-1 BELONGS TO A NOVEL FAMILY OF UBIQUITIN LIGASES WITH ZINC FINGERS AND AN UBIQUITIN-BINDING DOMAIN
The recently identified RNF125, or TRAC-1, is unique among ubiquitin ligases in being a positive regulator of T cell activation. In addition, TRAC-1 has been shown to down-modulate HIV replication and to inhibit pathogen-induced cytokine production. However, apart from the presence of an N-terminal...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2733222/ https://ncbi.nlm.nih.gov/pubmed/17990982 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070995 |
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