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T CELL REGULATOR RNF125/TRAC-1 BELONGS TO A NOVEL FAMILY OF UBIQUITIN LIGASES WITH ZINC FINGERS AND AN UBIQUITIN-BINDING DOMAIN

The recently identified RNF125, or TRAC-1, is unique among ubiquitin ligases in being a positive regulator of T cell activation. In addition, TRAC-1 has been shown to down-modulate HIV replication and to inhibit pathogen-induced cytokine production. However, apart from the presence of an N-terminal...

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Détails bibliographiques
Auteurs principaux: Giannini, Ana Lucia, Gao, Yifang, Bijlmakers, Marie-José
Format: Artigo
Langue:Inglês
Publié: 2008
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733222/
https://ncbi.nlm.nih.gov/pubmed/17990982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20070995
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