Concurrent targeting of BMI1 and CDK4/6 abrogates tumor growth in vitro and in vivo

Despite recent advances in cancer management and therapy, resistance to cytotoxic medications remains a major clinical challenge; hence, combination-based anti-cancer treatment regimens are currently gaining momentum. PTC-209 reduced BMI1 protein expression, while palbociclib inhibited CDK4, Rb, and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Elango, Ramesh, Vishnubalaji, Radhakrishnan, Manikandan, Muthurangan, Binhamdan, Sarah Ibrahim, Siyal, Abdul-Aziz, Alshawakir, Yasser A., Alfayez, Musaad, Aldahmash, Abdullah, Alajez, Nehad M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6757061/
https://ncbi.nlm.nih.gov/pubmed/31548560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-50140-0
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