Hedgehog Signaling Inhibition by Smoothened Antagonist BMS-833923 Reduces Osteoblast Differentiation and Ectopic Bone Formation of Human Skeletal (Mesenchymal) Stem Cells

BACKGROUND: Hedgehog (Hh) signaling is essential for osteoblast differentiation of mesenchymal progenitors during endochondral bone formation. However, the critical role of Hh signaling during adult bone remodeling remains to be elucidated. METHODS: A Smoothened (SMO) antagonist/Hedgehog inhibitor,...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: AlMuraikhi, Nihal, Almasoud, Nuha, Binhamdan, Sarah, Younis, Ghaydaa, Ali, Dalia, Manikandan, Muthurangan, Vishnubalaji, Radhakrishnan, Atteya, Muhammad, Siyal, Abdulaziz, Alfayez, Musaad, Aldahmash, Abdullah, Kassem, Moustapha, Alajez, Nehad M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6907053/
https://ncbi.nlm.nih.gov/pubmed/31871467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/3435901
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